Drug interactions
Linagliptin-metformin + Rifabutin
Severity: Moderate
Linagliptin-metformin and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an inducer of CYP3A4 and P-glycoprotein and can lower linagliptin concentrations. This may reduce the glucose-lowering efficacy of the combination product.
What this interaction means in plain words
Linagliptin-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases linagliptin clearance and lowers its exposure.
What to do
Monitor glycemic control and consider an alternative glucose-lowering agent if efficacy is lost during rifabutin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Linagliptin-metformin with Rifabutin?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is an inducer of CYP3A4 and P-glycoprotein and can lower linagliptin concentrations. This may reduce the glucose-lowering efficacy of the combination product.
How serious is the interaction between Linagliptin-metformin and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and consider an alternative glucose-lowering agent if efficacy is lost during rifabutin therapy.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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