Drug interactions
Linagliptin-metformin + Selegiline
Severity: Minor
Linagliptin-metformin and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance the glucose-lowering effect of antidiabetic drugs, raising hypoglycemia risk. Selegiline's effect on metformin is not well characterized.
What this interaction means in plain words
Linagliptin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
Mechanism not firmly established; MAO inhibition may enhance insulin sensitivity or glucose lowering.
What to do
Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic dosing if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Selegiline?
MediHelp rates the interaction as minor. Linagliptin-metformin and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors may enhance the glucose-lowering effect of antidiabetic drugs, raising hypoglycemia risk. Selegiline's effect on metformin is not well characterized.
How serious is the interaction between Linagliptin-metformin and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and adjust antidiabetic dosing if hypoglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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