Drug interactions
Linagliptin-metformin + Vandetanib
Severity: Moderate
Linagliptin-metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits the renal organic cation transporter OCT2, which helps clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Linagliptin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin reduces its clearance.
What to do
Monitor renal function and for signs of metformin toxicity or lactic acidosis. Consider reducing the metformin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Vandetanib?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits the renal organic cation transporter OCT2, which helps clear metformin. Metformin concentrations may rise, increasing the risk of gastrointestinal effects and, rarely, lactic acidosis, especially with renal impairment.
How serious is the interaction between Linagliptin-metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity or lactic acidosis. Consider reducing the metformin dose if adverse effects occur.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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