Drug interactions
Linezolid + Metformin-repaglinide
Severity: Moderate
Linezolid and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients taking insulin or oral antidiabetic drugs. This is most relevant with the repaglinide component.
What this interaction means in plain words
Linezolid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Metformin-repaglinide belongs to Endocrine.
Why it happens
Mechanism is not firmly established; possible enhancement of insulin secretion or sensitivity related to MAO inhibition.
What to do
Monitor blood glucose during linezolid therapy and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Linezolid and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid, a weak MAO inhibitor, has been associated with hypoglycemia in patients taking insulin or oral antidiabetic drugs. This is most relevant with the repaglinide component.
How serious is the interaction between Linezolid and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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