Drug interactions
Linezolid + Pimavanserin
Severity: Moderate
Linezolid and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin is a selective 5-HT2A inverse agonist and linezolid is a reversible MAO inhibitor. The combination could theoretically increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Clinical reports are lacking.
What this interaction means in plain words
Linezolid and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effects from MAO inhibition and 5-HT2A receptor modulation.
What to do
Monitor for signs of serotonin toxicity such as clonus, agitation, diaphoresis and hyperthermia during co-therapy. Withdraw one agent if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Linezolid with Pimavanserin?
MediHelp rates the interaction as moderate. Linezolid and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin is a selective 5-HT2A inverse agonist and linezolid is a reversible MAO inhibitor. The combination could theoretically increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Clinical reports are lacking.
How serious is the interaction between Linezolid and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as clonus, agitation, diaphoresis and hyperthermia during co-therapy. Withdraw one agent if symptoms appear.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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