Drug interactions
Linezolid + Salmeterol
Severity: Moderate
Linezolid and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a weak MAO inhibitor and may enhance cardiovascular effects of adrenergic drugs. Inhaled salmeterol has low systemic exposure, so clinically important effects are uncommon.
What this interaction means in plain words
Linezolid and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Salmeterol belongs to Respiratory.
Why it happens
MAO inhibition may potentiate sympathomimetic cardiovascular effects.
What to do
Monitor heart rate and blood pressure when salmeterol is started during linezolid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Salmeterol?
MediHelp rates the interaction as moderate. Linezolid and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid is a weak MAO inhibitor and may enhance cardiovascular effects of adrenergic drugs. Inhaled salmeterol has low systemic exposure, so clinically important effects are uncommon.
How serious is the interaction between Linezolid and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when salmeterol is started during linezolid therapy.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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