Drug interactions
Liotrix + Omeprazole
Severity: Minor
Liotrix and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression can reduce absorption of oral levothyroxine-containing products such as liotrix. Some patients on proton pump inhibitors need higher thyroid hormone doses, and TSH may rise.
What this interaction means in plain words
Liotrix and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Raised gastric pH may reduce dissolution and absorption of oral thyroid hormone tablets.
What to do
Check TSH 6 to 8 weeks after starting or stopping omeprazole and adjust the liotrix dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Liotrix with Omeprazole?
MediHelp rates the interaction as minor. Liotrix and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression can reduce absorption of oral levothyroxine-containing products such as liotrix. Some patients on proton pump inhibitors need higher thyroid hormone doses, and TSH may rise.
How serious is the interaction between Liotrix and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH 6 to 8 weeks after starting or stopping omeprazole and adjust the liotrix dose if needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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