Drug interactions
Liposomal doxorubicin + Mercaptopurine
Severity: Moderate
Liposomal doxorubicin and Mercaptopurine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause hepatotoxicity and myelosuppression, so overlapping toxicity is possible. Doxorubicin is also cleared hepatically, so impaired liver function may raise its exposure.
What this interaction means in plain words
Liposomal doxorubicin and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Mercaptopurine belongs to Oncology.
Why it happens
Additive hepatotoxicity and myelosuppression.
What to do
Monitor liver enzymes, bilirubin and blood counts regularly. Reduce doses if hepatic dysfunction or marked cytopenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Mercaptopurine
- Adenovirus types 4 and 7 live + Mercaptopurine Contraindicated
- Azathioprine + Mercaptopurine Contraindicated
- Bcg vaccine live + Mercaptopurine Contraindicated
- Febuxostat + Mercaptopurine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mercaptopurine Contraindicated
- Mercaptopurine + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Mercaptopurine?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Mercaptopurine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause hepatotoxicity and myelosuppression, so overlapping toxicity is possible. Doxorubicin is also cleared hepatically, so impaired liver function may raise its exposure.
How serious is the interaction between Liposomal doxorubicin and Mercaptopurine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, bilirubin and blood counts regularly. Reduce doses if hepatic dysfunction or marked cytopenia occurs.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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