Drug interactions
Liposomal doxorubicin + Olaparib
Severity: Moderate
Liposomal doxorubicin and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow function, so using them together can deepen and prolong neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding and may force treatment delays.
What this interaction means in plain words
Liposomal doxorubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from two agents that damage DNA or impair its repair.
What to do
Check complete blood counts regularly, particularly during the first treatment cycles. Reduce doses or delay treatment if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Liposomal doxorubicin with Olaparib?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow function, so using them together can deepen and prolong neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding and may force treatment delays.
How serious is the interaction between Liposomal doxorubicin and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly, particularly during the first treatment cycles. Reduce doses or delay treatment if significant cytopenias develop.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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