Drug interactions
Liposomal doxorubicin + Quinupristin / dalfopristin
Severity: Minor
Liposomal doxorubicin and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, but doxorubicin is only a minor CYP3A4 substrate, so a significant increase in exposure is unlikely. Clinical relevance is probably limited.
What this interaction means in plain words
Liposomal doxorubicin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by quinupristin/dalfopristin with limited relevance to doxorubicin.
What to do
No dose change is needed. Monitor for doxorubicin toxicity such as myelosuppression and mucositis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Liposomal doxorubicin with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4, but doxorubicin is only a minor CYP3A4 substrate, so a significant increase in exposure is unlikely. Clinical relevance is probably limited.
How serious is the interaction between Liposomal doxorubicin and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for doxorubicin toxicity such as myelosuppression and mucositis.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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