Drug interactions
Liposomal doxorubicin + Saquinavir
Severity: Moderate
Liposomal doxorubicin and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted saquinavir inhibits CYP3A4 and P-gp and may increase doxorubicin exposure and toxicity. Saquinavir also prolongs QT, adding cardiac concern.
What this interaction means in plain words
Liposomal doxorubicin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Saquinavir with ritonavir inhibits CYP3A4 and P-glycoprotein, reducing doxorubicin clearance.
What to do
Monitor blood counts, ECG and cardiac function, and reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Liposomal doxorubicin with Saquinavir?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted saquinavir inhibits CYP3A4 and P-gp and may increase doxorubicin exposure and toxicity. Saquinavir also prolongs QT, adding cardiac concern.
How serious is the interaction between Liposomal doxorubicin and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG and cardiac function, and reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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