Drug interactions
Liposomal doxorubicin + Streptozocin
Severity: Moderate
Liposomal doxorubicin and Streptozocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin has been reported to prolong doxorubicin half-life, potentially increasing its toxicity. Both drugs can also cause toxicity on their own, notably myelosuppression and cardiac or renal effects.
What this interaction means in plain words
Liposomal doxorubicin and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Streptozocin may reduce doxorubicin metabolism, but the mechanism is not firmly established.
What to do
Monitor blood counts, cardiac function and renal function. Consider reducing the doxorubicin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Frequently asked questions
Can I take Liposomal doxorubicin with Streptozocin?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptozocin has been reported to prolong doxorubicin half-life, potentially increasing its toxicity. Both drugs can also cause toxicity on their own, notably myelosuppression and cardiac or renal effects.
How serious is the interaction between Liposomal doxorubicin and Streptozocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and renal function. Consider reducing the doxorubicin dose if toxicity appears.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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