Drug interactions
Liraglutide + Methyclothiazide
Severity: Moderate
Liraglutide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can worsen glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of liraglutide. The effect is dose related and most relevant at initiation or dose increases.
What this interaction means in plain words
Liraglutide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides reduce insulin secretion and sensitivity, partly through potassium depletion, pharmacodynamically opposing liraglutide.
What to do
Monitor blood glucose when starting or increasing the thiazide dose and correct hypokalemia. Adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Methyclothiazide?
MediHelp rates the interaction as moderate. Liraglutide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can worsen glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of liraglutide. The effect is dose related and most relevant at initiation or dose increases.
How serious is the interaction between Liraglutide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or increasing the thiazide dose and correct hypokalemia. Adjust antidiabetic therapy if needed.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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