Drug interactions
Liraglutide + Sacubitril / valsartan
Severity: Minor
Liraglutide and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockade and neprilysin inhibition may improve insulin sensitivity, so glucose lowering with liraglutide can be slightly enhanced. Hypoglycemia is uncommon but possible, especially with insulin or sulfonylureas.
What this interaction means in plain words
Liraglutide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive improvement in insulin sensitivity; mechanism is not well established.
What to do
Monitor blood glucose when sacubitril/valsartan is started. Reduce doses of insulin or sulfonylureas if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Liraglutide and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockade and neprilysin inhibition may improve insulin sensitivity, so glucose lowering with liraglutide can be slightly enhanced. Hypoglycemia is uncommon but possible, especially with insulin or sulfonylureas.
How serious is the interaction between Liraglutide and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sacubitril/valsartan is started. Reduce doses of insulin or sulfonylureas if glucose falls.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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