Drug interactions
Liraglutide + Trifluoperazine
Severity: Minor
Liraglutide and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can alter glucose homeostasis, and trifluoperazine has a lower metabolic liability than many antipsychotics. Glycemic control with liraglutide may occasionally change in either direction.
What this interaction means in plain words
Liraglutide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Variable pharmacodynamic effects of phenothiazines on insulin secretion and sensitivity; not well characterized.
What to do
Monitor blood glucose when trifluoperazine is started or stopped. Adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Trifluoperazine?
MediHelp rates the interaction as minor. Liraglutide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can alter glucose homeostasis, and trifluoperazine has a lower metabolic liability than many antipsychotics. Glycemic control with liraglutide may occasionally change in either direction.
How serious is the interaction between Liraglutide and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trifluoperazine is started or stopped. Adjust antidiabetic therapy if control changes.
What other medicines interact with Liraglutide?
MediHelp also lists interactions of Liraglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Liraglutide page.
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