Drug interactions
Lisinopril + Probenecid
Severity: Minor
Lisinopril and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid might slightly reduce renal clearance of lisinopril, though lisinopril is mainly eliminated by glomerular filtration. Any increase in blood pressure lowering is expected to be small.
What this interaction means in plain words
Lisinopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisinopril belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Possible inhibition of renal tubular transport of lisinopril by probenecid; mechanism not firmly established.
What to do
Monitor blood pressure after starting probenecid and adjust the lisinopril dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Probenecid?
MediHelp rates the interaction as minor. Lisinopril and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid might slightly reduce renal clearance of lisinopril, though lisinopril is mainly eliminated by glomerular filtration. Any increase in blood pressure lowering is expected to be small.
How serious is the interaction between Lisinopril and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting probenecid and adjust the lisinopril dose if needed.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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