Drug interactions
Lisinopril + Saxagliptin-metformin
Severity: Moderate
Lisinopril and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which can raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Lisinopril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic enhancement of glucose lowering by ACE inhibition, plus possible reduction in renal clearance of metformin if renal function declines.
What to do
Monitor blood glucose and renal function, particularly after starting or changing the ACE inhibitor dose. Reassess metformin and saxagliptin dosing if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Lisinopril and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. They may also reduce renal function in susceptible patients, which can raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Lisinopril and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, particularly after starting or changing the ACE inhibitor dose. Reassess metformin and saxagliptin dosing if eGFR falls.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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