Drug interactions
lisinopril + sitagliptin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
DPP‑4 inhibitors have been associated with angioedema; concomitant ACE inhibitor use may increase susceptibility (rare but potentially serious).
Mechanism of action
ACE inhibition increases bradykinin; DPP‑4 inhibition may reduce degradation of bradykinin/substance P, raising angioedema risk.
Clinical management
Educate patients to report facial/tongue swelling or difficulty breathing; avoid DPP‑4 inhibitor if history of ACEI‑induced angioedema; discontinue implicated agent(s) if angioedema occurs.
Drug reference
References
- Sitagliptin (Januvia) Prescribing Information — FDA Label
- DPP‑4 inhibitors and ACE inhibitors: Angioedema risk — Lexicomp
Frequently asked questions
Can I take lisinopril with sitagliptin?
The interaction is rated: Moderate. DPP‑4 inhibitors have been associated with angioedema; concomitant ACE inhibitor use may increase susceptibility (rare but potentially serious).
How serious is the interaction between lisinopril and sitagliptin?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between lisinopril and sitagliptin managed?
Educate patients to report facial/tongue swelling or difficulty breathing; avoid DPP‑4 inhibitor if history of ACEI‑induced angioedema; discontinue implicated agent(s) if angioedema occurs.
Why do lisinopril and sitagliptin interact?
ACE inhibition increases bradykinin; DPP‑4 inhibition may reduce degradation of bradykinin/substance P, raising angioedema risk.
Full monographs, dosing and an interaction checker in the MediHelp app
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