Drug interactions
Lisinopril + Tolazamide
Severity: Moderate
Lisinopril and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is most likely soon after starting the ACE inhibitor or in patients with good glycemic control.
What this interaction means in plain words
Lisinopril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
ACE inhibition may increase insulin sensitivity, producing an additive glucose-lowering effect with the sulfonylurea.
What to do
Monitor blood glucose when lisinopril is started or the dose changed. Lower the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Lisinopril with Tolazamide?
MediHelp rates the interaction as moderate. Lisinopril and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance the glucose-lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is most likely soon after starting the ACE inhibitor or in patients with good glycemic control.
How serious is the interaction between Lisinopril and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lisinopril is started or the dose changed. Lower the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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