Drug interactions
Lisinopril + Tolbutamide
Severity: Moderate
Lisinopril and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The risk is greatest early after starting the ACE inhibitor.
What this interaction means in plain words
Lisinopril and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Tolbutamide belongs to Endocrine.
Why it happens
ACE inhibition may enhance insulin sensitivity, adding to the hypoglycemic action of the sulfonylurea.
What to do
Monitor blood glucose after starting lisinopril and teach the patient the signs of hypoglycemia. Reduce the tolbutamide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Lisinopril with Tolbutamide?
MediHelp rates the interaction as moderate. Lisinopril and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can potentiate the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The risk is greatest early after starting the ACE inhibitor.
How serious is the interaction between Lisinopril and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting lisinopril and teach the patient the signs of hypoglycemia. Reduce the tolbutamide dose if needed.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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