Drug interactions
Lisinopril + Tolfenamic acid
Severity: Moderate
Lisinopril and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid can weaken the antihypertensive action of lisinopril. The combination may also impair renal function and raise potassium in susceptible patients.
What this interaction means in plain words
Lisinopril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes fluid retention and reduced renal perfusion, opposing ACE inhibition.
What to do
Monitor blood pressure, serum creatinine and potassium. Limit NSAID dose and duration, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Lisinopril with Tolfenamic acid?
MediHelp rates the interaction as moderate. Lisinopril and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid can weaken the antihypertensive action of lisinopril. The combination may also impair renal function and raise potassium in susceptible patients.
How serious is the interaction between Lisinopril and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium. Limit NSAID dose and duration, and ensure adequate hydration.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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