Drug interactions
Lisocabtagene maraleucel + Oxaliplatin
Severity: Major
Lisocabtagene maraleucel and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can add to the cytopenias and infection risk seen with CAR-T therapy. It may also damage infused CAR-T cells and reduce their expansion and efficacy if given outside planned regimens.
What this interaction means in plain words
Lisocabtagene maraleucel and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisocabtagene maraleucel belongs to Oncology; Oxaliplatin belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression, with possible cytotoxic effect on CAR-T cells.
What to do
Avoid oxaliplatin around CAR-T infusion unless part of a planned regimen by the treating team. Monitor blood counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Oxaliplatin?
MediHelp rates the interaction as major. Lisocabtagene maraleucel and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cytotoxic chemotherapy can add to the cytopenias and infection risk seen with CAR-T therapy. It may also damage infused CAR-T cells and reduce their expansion and efficacy if given outside planned regimens.
How serious is the interaction between Lisocabtagene maraleucel and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oxaliplatin around CAR-T infusion unless part of a planned regimen by the treating team. Monitor blood counts and watch for infection.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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