Drug interactions
Lisocabtagene maraleucel + Sirolimus
Severity: Major
Lisocabtagene maraleucel and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressants such as sirolimus may impair CAR T-cell expansion and persistence, potentially reducing efficacy. Patients are also at high risk of infection after CAR T therapy.
What this interaction means in plain words
Lisocabtagene maraleucel and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisocabtagene maraleucel belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition suppresses T-cell activation and proliferation, which may antagonize CAR T-cell function.
What to do
Avoid sirolimus around leukapheresis and CAR T infusion unless clearly required. Coordinate any immunosuppressant use with the treating oncology team and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Lisocabtagene maraleucel
Frequently asked questions
Can I take Lisocabtagene maraleucel with Sirolimus?
MediHelp rates the interaction as major. Lisocabtagene maraleucel and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Immunosuppressants such as sirolimus may impair CAR T-cell expansion and persistence, potentially reducing efficacy. Patients are also at high risk of infection after CAR T therapy.
How serious is the interaction between Lisocabtagene maraleucel and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sirolimus around leukapheresis and CAR T infusion unless clearly required. Coordinate any immunosuppressant use with the treating oncology team and monitor for infection.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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