Drug interactions
Lithium + Lornoxicam
Severity: Major
Lithium and Lornoxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can reduce renal lithium clearance and raise serum lithium, potentially to toxic concentrations. Symptoms include tremor, nausea, ataxia and confusion.
What this interaction means in plain words
Lithium and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lithium belongs to Central Nervous System; Lornoxicam belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and lithium excretion.
What to do
Prefer paracetamol or another alternative. If an NSAID is needed, monitor serum lithium within the first week and after dose changes, and reduce lithium as required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lithium with Lornoxicam?
MediHelp rates the interaction as major. Lithium and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as lornoxicam can reduce renal lithium clearance and raise serum lithium, potentially to toxic concentrations. Symptoms include tremor, nausea, ataxia and confusion.
How serious is the interaction between Lithium and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or another alternative. If an NSAID is needed, monitor serum lithium within the first week and after dose changes, and reduce lithium as required.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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