Drug interactions
Lithium + Midazolam
Severity: Minor
Lithium and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can cause drowsiness, tremor and cognitive slowing, which may add to the sedative effect of midazolam. The interaction is mainly additive CNS impairment and is usually modest.
What this interaction means in plain words
Lithium and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lithium belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS effects; no significant pharmacokinetic interaction is established.
What to do
Monitor for excessive sedation and confusion when midazolam is given to patients on lithium, and use the lowest effective midazolam dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Midazolam?
MediHelp rates the interaction as minor. Lithium and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium can cause drowsiness, tremor and cognitive slowing, which may add to the sedative effect of midazolam. The interaction is mainly additive CNS impairment and is usually modest.
How serious is the interaction between Lithium and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and confusion when midazolam is given to patients on lithium, and use the lowest effective midazolam dose.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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