Drug interactions
Lithium + Nisoldipine
Severity: Minor
Lithium and Nisoldipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers have been reported in rare cases to precipitate neurotoxicity in patients taking lithium. Evidence for nisoldipine specifically is limited.
What this interaction means in plain words
Lithium and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lithium belongs to Central Nervous System; Nisoldipine belongs to Cardiovascular.
Why it happens
Not well established; possible additive effects on neuronal calcium handling.
What to do
Monitor for tremor, ataxia, confusion and other neurologic signs when combining. Check lithium level and reduce doses if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Lithium with Nisoldipine?
MediHelp rates the interaction as minor. Lithium and Nisoldipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers have been reported in rare cases to precipitate neurotoxicity in patients taking lithium. Evidence for nisoldipine specifically is limited.
How serious is the interaction between Lithium and Nisoldipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, ataxia, confusion and other neurologic signs when combining. Check lithium level and reduce doses if symptoms emerge.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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