Drug interactions
Lithium + Osilodrostat
Severity: Moderate
Lithium and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so taking them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk rises with electrolyte disturbance, bradycardia or underlying heart disease.
What this interaction means in plain words
Lithium and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and repeat it after initiation or dose changes, and correct potassium and magnesium. Monitor serum lithium concentrations, and reconsider the combination if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Lithium with Osilodrostat?
MediHelp rates the interaction as moderate. Lithium and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so taking them together may add to the risk of ventricular arrhythmias including torsades de pointes. The risk rises with electrolyte disturbance, bradycardia or underlying heart disease.
How serious is the interaction between Lithium and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after initiation or dose changes, and correct potassium and magnesium. Monitor serum lithium concentrations, and reconsider the combination if the QTc becomes markedly prolonged.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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