Drug interactions
Lithium + Osimertinib
Severity: Moderate
Lithium and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and used together they may raise the risk of arrhythmia. Osimertinib's QT effect is modest, so the added risk is mainly in patients with other risk factors.
What this interaction means in plain words
Lithium and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and monitor periodically, and correct electrolyte abnormalities. Reassess the combination if QTc becomes markedly prolonged or the patient develops arrhythmic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Lithium with Osimertinib?
MediHelp rates the interaction as moderate. Lithium and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and used together they may raise the risk of arrhythmia. Osimertinib's QT effect is modest, so the added risk is mainly in patients with other risk factors.
How serious is the interaction between Lithium and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, and correct electrolyte abnormalities. Reassess the combination if QTc becomes markedly prolonged or the patient develops arrhythmic symptoms.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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