Drug interactions
Lithium + Solifenacin
Severity: Moderate
Lithium and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can cause T-wave changes, sinus node dysfunction and QT prolongation, particularly at elevated levels. Solifenacin has a dose-related QT effect, so the combination may add to the arrhythmia risk in susceptible patients.
What this interaction means in plain words
Lithium and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive effects on cardiac repolarization and QT interval.
What to do
Keep serum lithium within the therapeutic range and correct electrolyte abnormalities. Obtain an ECG in patients with heart disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Solifenacin?
MediHelp rates the interaction as moderate. Lithium and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium can cause T-wave changes, sinus node dysfunction and QT prolongation, particularly at elevated levels. Solifenacin has a dose-related QT effect, so the combination may add to the arrhythmia risk in susceptible patients.
How serious is the interaction between Lithium and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep serum lithium within the therapeutic range and correct electrolyte abnormalities. Obtain an ECG in patients with heart disease or other QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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