Drug interactions
Lithium + Voriconazole
Severity: Moderate
Lithium and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may increase the chance of ventricular arrhythmia including torsades de pointes. The risk rises with lithium toxicity, electrolyte disturbances or existing cardiac disease.
What this interaction means in plain words
Lithium and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Check baseline ECG, potassium, magnesium and calcium, and monitor the ECG during co-administration. Monitor serum lithium levels to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Voriconazole?
MediHelp rates the interaction as moderate. Lithium and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may increase the chance of ventricular arrhythmia including torsades de pointes. The risk rises with lithium toxicity, electrolyte disturbances or existing cardiac disease.
How serious is the interaction between Lithium and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG, potassium, magnesium and calcium, and monitor the ECG during co-administration. Monitor serum lithium levels to avoid toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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