Drug interactions
Lofepramine + Meperidine
Severity: Major
Lofepramine and Meperidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with serotonin reuptake activity, and meperidine also has serotonergic activity. The combination may cause serotonin syndrome and may lower seizure threshold.
What this interaction means in plain words
Lofepramine and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from reuptake inhibition by both agents.
What to do
Use a non-serotonergic analgesic such as morphine; if combined, monitor for serotonin toxicity and seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Lofepramine with Meperidine?
MediHelp rates the interaction as major. Lofepramine and Meperidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofepramine is a tricyclic antidepressant with serotonin reuptake activity, and meperidine also has serotonergic activity. The combination may cause serotonin syndrome and may lower seizure threshold.
How serious is the interaction between Lofepramine and Meperidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-serotonergic analgesic such as morphine; if combined, monitor for serotonin toxicity and seizures.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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