Drug interactions
Lofepramine + Midazolam
Severity: Moderate
Lofepramine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative properties, and adding midazolam increases drowsiness and psychomotor impairment. The risk of excessive sedation is higher in older adults.
What this interaction means in plain words
Lofepramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABAergic and antihistaminic/anticholinergic effects.
What to do
Monitor sedation and reduce the midazolam dose as needed; advise patients to avoid driving and other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Lofepramine with Midazolam?
MediHelp rates the interaction as moderate. Lofepramine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative properties, and adding midazolam increases drowsiness and psychomotor impairment. The risk of excessive sedation is higher in older adults.
How serious is the interaction between Lofepramine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and reduce the midazolam dose as needed; advise patients to avoid driving and other hazardous tasks.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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