Drug interactions
Lofepramine + Perphenazine
Severity: Moderate
Lofepramine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and combined use increases the risk of ventricular arrhythmias. Perphenazine also inhibits CYP2D6 and may raise tricyclic concentrations, with additive anticholinergic and sedative effects.
What this interaction means in plain words
Lofepramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with CYP2D6 inhibition by perphenazine raising tricyclic exposure.
What to do
Obtain a baseline ECG and monitor the QTc, and keep potassium and magnesium normal. Reduce the lofepramine dose if anticholinergic or cardiac adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Lofepramine with Perphenazine?
MediHelp rates the interaction as moderate. Lofepramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and combined use increases the risk of ventricular arrhythmias. Perphenazine also inhibits CYP2D6 and may raise tricyclic concentrations, with additive anticholinergic and sedative effects.
How serious is the interaction between Lofepramine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc, and keep potassium and magnesium normal. Reduce the lofepramine dose if anticholinergic or cardiac adverse effects emerge.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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