Drug interactions
Lofepramine + Solifenacin
Severity: Moderate
Lofepramine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, has anticholinergic properties that add to those of solifenacin. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
What this interaction means in plain words
Lofepramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects of both drugs.
What to do
Monitor for urinary retention, constipation, and cognitive effects, particularly in older adults, and lower the doses or choose an alternative if anticholinergic burden becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Lofepramine with Solifenacin?
MediHelp rates the interaction as moderate. Lofepramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, has anticholinergic properties that add to those of solifenacin. This can cause dry mouth, constipation, urinary retention, blurred vision and confusion.
How serious is the interaction between Lofepramine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, and cognitive effects, particularly in older adults, and lower the doses or choose an alternative if anticholinergic burden becomes problematic.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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