Drug interactions
Lofexidine + Maprotiline
Severity: Moderate
Lofexidine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a sedating alpha-2 agonist that lowers blood pressure and heart rate, and maprotiline adds sedation and orthostatic effects. Lofexidine also prolongs the QT interval, and tricyclic-type antidepressants may reduce its antihypertensive effect by opposing alpha-2 mediated actions.
What this interaction means in plain words
Lofexidine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension, additive QT effects, and possible pharmacodynamic antagonism of alpha-2 agonism by the antidepressant.
What to do
Monitor blood pressure, pulse, sedation and ECG during opioid withdrawal treatment. Adjust the lofexidine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lofexidine and Maprotiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Maprotiline?
MediHelp rates the interaction as moderate. Lofexidine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a sedating alpha-2 agonist that lowers blood pressure and heart rate, and maprotiline adds sedation and orthostatic effects. Lofexidine also prolongs the QT interval, and tricyclic-type antidepressants may reduce its antihypertensive effect by opposing alpha-2 mediated actions.
How serious is the interaction between Lofexidine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, pulse, sedation and ECG during opioid withdrawal treatment. Adjust the lofexidine dose according to response.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
