Drug interactions
Lofexidine + Metaxalone
Severity: Moderate
Lofexidine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine, a central alpha-2 agonist, causes sedation, hypotension and bradycardia, and may add to metaxalone's sedative effects. Dizziness and falls may be more likely.
What this interaction means in plain words
Lofexidine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression, with lofexidine adding central sympatholytic effects.
What to do
Monitor blood pressure, heart rate and sedation level, especially during opioid withdrawal treatment. Lower the dose of one agent if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Metaxalone?
MediHelp rates the interaction as moderate. Lofexidine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine, a central alpha-2 agonist, causes sedation, hypotension and bradycardia, and may add to metaxalone's sedative effects. Dizziness and falls may be more likely.
How serious is the interaction between Lofexidine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation level, especially during opioid withdrawal treatment. Lower the dose of one agent if symptomatic.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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