Drug interactions
Lofexidine + Nebivolol
Severity: Major
Lofexidine and Nebivolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and a beta-blocker adds to these effects. Together they can cause excessive bradycardia, hypotension, and syncope.
What this interaction means in plain words
Lofexidine and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lofexidine belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: central sympatholytic action plus beta-adrenergic blockade.
What to do
Monitor pulse and blood pressure closely, especially at initiation and dose changes, and reduce or hold doses if symptomatic bradycardia or hypotension occurs. Consider an alternative if the baseline heart rate is low.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Nebivolol?
MediHelp rates the interaction as major. Lofexidine and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate, and a beta-blocker adds to these effects. Together they can cause excessive bradycardia, hypotension, and syncope.
How serious is the interaction between Lofexidine and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure closely, especially at initiation and dose changes, and reduce or hold doses if symptomatic bradycardia or hypotension occurs. Consider an alternative if the baseline heart rate is low.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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