Drug interactions
Lofexidine + Sufentanil
Severity: Moderate
Lofexidine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and sufentanil is a potent opioid that also depresses respiration. Combining them can deepen sedation and lower blood pressure and heart rate, and may increase the risk of respiratory depression.
What this interaction means in plain words
Lofexidine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression, with additive hypotensive and bradycardic effects of lofexidine.
What to do
Monitor sedation level, respiratory rate, blood pressure and heart rate, and titrate the opioid to the lowest effective dose. Ensure resuscitation equipment is available in the perioperative setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Lofexidine with Sufentanil?
MediHelp rates the interaction as moderate. Lofexidine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and sufentanil is a potent opioid that also depresses respiration. Combining them can deepen sedation and lower blood pressure and heart rate, and may increase the risk of respiratory depression.
How serious is the interaction between Lofexidine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory rate, blood pressure and heart rate, and titrate the opioid to the lowest effective dose. Ensure resuscitation equipment is available in the perioperative setting.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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