Drug interactions
Lofexidine + Tetrabenazine
Severity: Moderate
Lofexidine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and tetrabenazine causes a modest dose-related QTc increase. Combined use may raise the risk of torsades de pointes, particularly with bradycardia, low potassium or magnesium, or CYP2D6 poor metabolizer status.
What this interaction means in plain words
Lofexidine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QTc interval.
What to do
Perform a baseline and follow-up ECG and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Lofexidine with Tetrabenazine?
MediHelp rates the interaction as moderate. Lofexidine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and tetrabenazine causes a modest dose-related QTc increase. Combined use may raise the risk of torsades de pointes, particularly with bradycardia, low potassium or magnesium, or CYP2D6 poor metabolizer status.
How serious is the interaction between Lofexidine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline and follow-up ECG and correct electrolyte disturbances. Avoid the combination in patients with congenital long QT syndrome or other significant QT risk factors.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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