Drug interactions
Lofexidine + Treprostinil
Severity: Moderate
Lofexidine and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and lofexidine reduces sympathetic tone, blood pressure and heart rate. Used together they may cause additive hypotension and symptomatic bradycardia.
What this interaction means in plain words
Lofexidine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Treprostinil belongs to Cardiovascular.
Why it happens
Additive hypotensive pharmacodynamic effects from prostacyclin-mediated vasodilation and central sympatholysis.
What to do
Monitor blood pressure and heart rate when starting or changing doses, and counsel patients regarding dizziness and syncope. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Lofexidine with Treprostinil?
MediHelp rates the interaction as moderate. Lofexidine and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator and lofexidine reduces sympathetic tone, blood pressure and heart rate. Used together they may cause additive hypotension and symptomatic bradycardia.
How serious is the interaction between Lofexidine and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses, and counsel patients regarding dizziness and syncope. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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