Drug interactions
Lofexidine + Voclosporin
Severity: Moderate
Lofexidine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and lofexidine also prolongs the QT interval. Combined use may increase the risk of arrhythmia, particularly with electrolyte disturbances or other QT-prolonging factors.
What this interaction means in plain words
Lofexidine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive prolongation of the QTc interval.
What to do
Monitor ECG and correct potassium and magnesium abnormalities during combined use. Avoid the combination in patients with congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Lofexidine with Voclosporin?
MediHelp rates the interaction as moderate. Lofexidine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin has been associated with QT prolongation at supratherapeutic exposures, and lofexidine also prolongs the QT interval. Combined use may increase the risk of arrhythmia, particularly with electrolyte disturbances or other QT-prolonging factors.
How serious is the interaction between Lofexidine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium abnormalities during combined use. Avoid the combination in patients with congenital long QT syndrome.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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