Drug interactions
Lomitapide + Olanzapine
Severity: Minor
Lomitapide and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a CYP3A4 substrate, but olanzapine is not a significant CYP3A4 inhibitor, so a meaningful rise in lomitapide levels is not expected. Both drugs can affect the liver, with lomitapide causing hepatotoxicity and olanzapine causing transaminase elevations.
What this interaction means in plain words
Lomitapide and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; possible additive hepatic effects.
What to do
Monitor liver enzymes according to lomitapide labeling. No dose adjustment is needed for the combination alone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Olanzapine?
MediHelp rates the interaction as minor. Lomitapide and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide is a CYP3A4 substrate, but olanzapine is not a significant CYP3A4 inhibitor, so a meaningful rise in lomitapide levels is not expected. Both drugs can affect the liver, with lomitapide causing hepatotoxicity and olanzapine causing transaminase elevations.
How serious is the interaction between Lomitapide and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes according to lomitapide labeling. No dose adjustment is needed for the combination alone.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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