Drug interactions
Lomitapide + Pimozide
Severity: Moderate
Lomitapide and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is reported to raise lomitapide exposure through CYP3A4 inhibition, which can increase lomitapide's hepatotoxicity and gastrointestinal adverse effects. The clinical significance is uncertain because pimozide is only a weak CYP3A4 inhibitor, but lomitapide is highly sensitive to CYP3A4 changes.
What this interaction means in plain words
Lomitapide and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Pimozide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lomitapide, which increases its plasma concentrations.
What to do
Monitor liver enzymes and gastrointestinal tolerability closely, and keep the lomitapide dose within labeled limits for patients on CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Pimozide?
MediHelp rates the interaction as moderate. Lomitapide and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide is reported to raise lomitapide exposure through CYP3A4 inhibition, which can increase lomitapide's hepatotoxicity and gastrointestinal adverse effects. The clinical significance is uncertain because pimozide is only a weak CYP3A4 inhibitor, but lomitapide is highly sensitive to CYP3A4 changes.
How serious is the interaction between Lomitapide and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability closely, and keep the lomitapide dose within labeled limits for patients on CYP3A4 inhibitors. Reduce the lomitapide dose if transaminases rise.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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