Drug interactions
Lomitapide + Rabeprazole
Severity: Minor
Lomitapide and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole is not a recognized clinically significant CYP3A4 inhibitor, and no established interaction with lomitapide exists. Lomitapide is highly sensitive to CYP3A4 inhibition, but PPIs are not on the list of inhibitors that restrict its dose.
What this interaction means in plain words
Lomitapide and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; theoretical weak CYP3A4 effect only.
What to do
No dose adjustment is needed. Monitor liver enzymes as usual during lomitapide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Rabeprazole?
MediHelp rates the interaction as minor. Lomitapide and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rabeprazole is not a recognized clinically significant CYP3A4 inhibitor, and no established interaction with lomitapide exists. Lomitapide is highly sensitive to CYP3A4 inhibition, but PPIs are not on the list of inhibitors that restrict its dose.
How serious is the interaction between Lomitapide and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes as usual during lomitapide therapy.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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