Drug interactions
Lonafarnib + Olanzapine
Severity: Minor
Lonafarnib and Olanzapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and the claim that olanzapine meaningfully raises its exposure is not well supported because olanzapine is not a recognized CYP3A inhibitor. Any interaction is therefore uncertain.
What this interaction means in plain words
Lonafarnib and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
No established mechanism; olanzapine is not a known CYP3A inhibitor.
What to do
No dose change is needed. Monitor the ECG and report palpitations or syncope as part of routine lonafarnib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonafarnib and Olanzapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olanzapine
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Olanzapine?
MediHelp rates the interaction as minor. Lonafarnib and Olanzapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, and the claim that olanzapine meaningfully raises its exposure is not well supported because olanzapine is not a recognized CYP3A inhibitor. Any interaction is therefore uncertain.
How serious is the interaction between Lonafarnib and Olanzapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor the ECG and report palpitations or syncope as part of routine lonafarnib care.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
