Drug interactions
Lonafarnib + Rabeprazole
Severity: Moderate
Lonafarnib and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and also a CYP3A inhibitor. Rabeprazole has only minor CYP3A involvement, so a significant interaction is not well established.
What this interaction means in plain words
Lonafarnib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak mutual CYP3A-related effects; the clinical effect of rabeprazole on lonafarnib is not well characterized.
What to do
Monitor for lonafarnib adverse effects such as gastrointestinal toxicity and for changes in rabeprazole response. Adjust lonafarnib dose per labeling if a CYP3A inhibitor is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Rabeprazole?
MediHelp rates the interaction as moderate. Lonafarnib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and also a CYP3A inhibitor. Rabeprazole has only minor CYP3A involvement, so a significant interaction is not well established.
How serious is the interaction between Lonafarnib and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects such as gastrointestinal toxicity and for changes in rabeprazole response. Adjust lonafarnib dose per labeling if a CYP3A inhibitor is required.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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