Drug interactions
Lonafarnib + Rifaximin
Severity: Minor
Lonafarnib and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and may modestly increase absorption of rifaximin. Because rifaximin has very low systemic uptake, the clinical effect is expected to be small.
What this interaction means in plain words
Lonafarnib and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Rifaximin belongs to Anti Bacterial.
Why it happens
Weak inhibition of intestinal P-glycoprotein by lonafarnib reduces efflux of rifaximin.
What to do
No routine adjustment is needed. Watch for rifaximin adverse effects in patients with hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Rifaximin?
MediHelp rates the interaction as minor. Lonafarnib and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and may modestly increase absorption of rifaximin. Because rifaximin has very low systemic uptake, the clinical effect is expected to be small.
How serious is the interaction between Lonafarnib and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for rifaximin adverse effects in patients with hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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