Drug interactions
Lonafarnib + Tenofovir disoproxil
Severity: Minor
Lonafarnib and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor, and tenofovir disoproxil is a P-gp substrate. Absorption of tenofovir may increase slightly, but a meaningful clinical effect is unlikely.
What this interaction means in plain words
Lonafarnib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak P-gp inhibition by lonafarnib may increase tenofovir disoproxil absorption.
What to do
No routine adjustment needed; monitor renal function and tenofovir adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Lonafarnib and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor, and tenofovir disoproxil is a P-gp substrate. Absorption of tenofovir may increase slightly, but a meaningful clinical effect is unlikely.
How serious is the interaction between Lonafarnib and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor renal function and tenofovir adverse effects.
What other medicines interact with Lonafarnib?
MediHelp also lists interactions of Lonafarnib with, for example, Alfuzosin, Amobarbital, Apalutamide. The full list is on the Lonafarnib page.
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