Drug interactions
Lonafarnib + Theophylline
Severity: Moderate
Lonafarnib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a CYP3A inhibitor and may modestly increase theophylline exposure, since CYP3A4 is a minor route of theophylline clearance. The risk is toxicity such as tachycardia, vomiting and seizures if levels rise.
What this interaction means in plain words
Lonafarnib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Lonafarnib inhibits CYP3A4, reducing a minor pathway of theophylline metabolism.
What to do
Monitor theophylline serum levels and symptoms of toxicity, and reduce the theophylline dose if concentrations increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Theophylline?
MediHelp rates the interaction as moderate. Lonafarnib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a CYP3A inhibitor and may modestly increase theophylline exposure, since CYP3A4 is a minor route of theophylline clearance. The risk is toxicity such as tachycardia, vomiting and seizures if levels rise.
How serious is the interaction between Lonafarnib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and symptoms of toxicity, and reduce the theophylline dose if concentrations increase.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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