Drug interactions
Lonafarnib + Ulipristal
Severity: Moderate
Lonafarnib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A4 inhibitor and may markedly increase ulipristal exposure, raising the risk of adverse effects.
What this interaction means in plain words
Lonafarnib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lonafarnib inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Choose a copper intrauterine device or levonorgestrel instead. If ulipristal is used, monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Ulipristal?
MediHelp rates the interaction as moderate. Lonafarnib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A4 inhibitor and may markedly increase ulipristal exposure, raising the risk of adverse effects.
How serious is the interaction between Lonafarnib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a copper intrauterine device or levonorgestrel instead. If ulipristal is used, monitor for adverse effects.
What other medicines interact with Lonafarnib?
MediHelp also lists interactions of Lonafarnib with, for example, Alfuzosin, Amobarbital, Apalutamide. The full list is on the Lonafarnib page.
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